Pregenetic Diagnosis and Screening [PGD and PGS in Surat]

Female First Hospital offers advanced PGD & PGS testing in Surat — genetic screening of embryos before transfer to improve IVF success and reduce the risk of miscarriage. Under the care of Dr. Sweta Patel, our genetic screening helps couples at risk of passing on inherited conditions have a healthy pregnancy.

What Is PGD (Preimplantation Genetic Diagnosis)?

Preimplantation Genetic Diagnosis (PGD) was developed as an alternative to prenatal diagnosis for couples at risk of passing on serious genetic diseases to their children. It uses the IVF (test tube baby) technique to test embryos for genetic disorders before they are implanted in the womb — avoiding the need for later pregnancy termination.

PGD can help detect a growing number of genetic disorders, though not all conditions can be diagnosed this way. Genetic disorders may be due to a single-gene defect (such as cystic fibrosis) or a chromosomal abnormality. In single-gene disorders, the embryo’s genes can be examined directly. Some conditions, such as Duchenne’s muscular dystrophy or haemophilia, affect only males, in which case the sex of the embryo is determined and only female embryos are transferred.

How Is PGD Performed?

PGD is carried out as part of an IVF–ICSI cycle:

• Standard IVF is used when FISH analysis is required; ICSI is used when semen is abnormal or PCR analysis is needed, to avoid contamination with sperm DNA.
• A single cell is removed from an early embryo through a small opening in its outer coat, under the microscope, without harming its ability to develop.
• The cell is analysed for genetic disorders before the embryo is transferred.
• A newer technique, comparative genomic hybridisation (CGH), allows cells to be removed at the blastocyst stage (day 5), when more cells can be analysed for greater confidence.

Because PGD works best on day 5–6 embryos, it is often combined with blastocyst culture & transfer.

Who Is PGD Advised For?

• Couples with repeated pregnancy loss due to genetic disorders
• Couples who have a child with a genetic disease and are at high risk of having another
• Couples where one or both partners carry a known genetic condition

What Is PGS (Preimplantation Genetic Screening)?

Preimplantation Genetic Screening (PGS), also called aneuploidy screening, checks embryos for a normal number of chromosomes (commonly chromosomes 21, 18, 16 and 13). Aneuploidy — where an embryo has the wrong number of chromosomes — is a major cause of failed implantation and miscarriage. Only chromosomally normal embryos are selected for transfer.

PGS is often considered for older women, those with a history of recurrent miscarriage, or repeated IVF failure despite good-quality embryos. Your specialist will advise whether PGS is likely to benefit your specific case.

Accuracy & Considerations

As with all tests, there is a small possibility of a false-positive or false-negative result (figures to be confirmed by the clinic), partly because some embryos show variation between cells (mosaicism). For this reason, prenatal testing during pregnancy may still be recommended. It is also possible that no normal embryos are found in a cycle, in which case none would be suitable for transfer. Our team explains all of this clearly before you decide.

Why Choose Female First Hospital for PGD & PGS in Surat

• Integrated genetic testing — PGD & PGS carried out within our own IVF & fertility treatments, with support from our genetic centre.
• Experienced specialist — care led by Dr. Sweta Patel, with 15+ years in reproductive medicine.
• Complete diagnostic support — backed by our diagnostic testing services.
• Clear, honest counselling — full explanation of benefits, limits and accuracy before any decision.

Book a Consultation

To find out whether PGD or PGS testing is right for you, book a consultation with Dr. Sweta Patel at Female First Hospital, Surat.